Several diseases and conditions are marked by severe swelling. Sound familiar? Here are twelve tips to help you beat the endo belly bloat battle-and win: “The second is that the endometriosis lesions can flare at different parts of the menstrual cycle, which can cause an immune response, which includes swelling.” “ causes scar tissue that can bind up the abdominal organs and slow down the intestines,” she explains. This “endo baby bump” is often painful and uncomfortable, and can take a toll on self-image.Īccording to Amanda Malachesky, a Functional Nutrition Practitioner, owner of Confluence Nutrition, and longtime endometriosis patient, there are two primary reasons for bloating with endometriosis. Morse Fellowship, Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease, CPRIT Core Facility Support Award RP210227, National Cancer Institute Center Support Grant P30CA125123, NIH/NCI R01CA220297 and NIH/NCI R01CA216426 intramural funds from the Dan L Duncan Comprehensive Cancer Center.Like everything else with endometriosis, severe bloating, also known as “endo belly” can be complex and varied from person to person. Further support was provided by a Stephen I. This work was funded in part by National Institutes of Health/National Institute of Child Health and Human Development grants R01HD102680, R01HD065435 and R00HD080742. “We are interested in determining whether changes in the gut microbiome could affect bowel conditions and the possibility of controlling them by modifying the microbiome or with their metabolites,” Kommagani said. Women with endometriosis also tend to have bowel issues, such as colitis or inflammatory bowel syndrome. “We are investigating whether microbiome metabolites in human stool samples could be a useful diagnostic tool and also whether some of these metabolites could be used as a treatment strategy.” “Endometriosis is typically diagnosed with ultrasound, and an invasive procedure is necessary to characterize the lesion well,” Kommagani said. The findings also suggested that studying microbiome metabolites in human stool samples could be used as a diagnostic tool. “We are currently investigating this possibility,” Kommagani said. The findings suggest that certain microbiome communities and/or their metabolites can contribute to endometriosis progression and that modifying the composition of these communities could help control the condition in human patients. Supporting the role of microbiome metabolites in disease progression, Kommagani and his colleagues found that treatment of endometriotic cells and mice with the metabolite called quinic acid significantly enhanced the cellular proliferation and endometriotic lesion growth, respectively. The team also discovered a novel signature of microbiome-derived metabolites, products produced by the microbes, that were significantly altered in feces of mice with endometriosis. On the other hand, the uterine microbiome did not seem to affect disease progression. These findings suggest that altered gut bacteria drive disease progression. Furthermore, when gut microbiome-free mice received gut microbiota from mice with endometriosis, the lesions grew as large as those in mice retaining their microbiome. The researchers found that mice lacking gut microbiome had smaller endometriotic lesions than mice with a microbiome. Rama Kommagani, associate professor in the Departments of Pathology and Immunology and of Molecular Virology and Microbiology at Baylor. “To investigate the role of the microbiome in endometriosis we first implemented a novel mouse model of the condition in which we eliminated the microbiome using antibiotics,” said lead author Dr. In this study published in the journal Cell Death & Discovery, researchers at Baylor College of Medicine discovered that an altered gut microbiome plays a pivotal role in endometriosis disease progression in an animal model. Despite decades of research, little is known about the factors that contribute to the development of endometriosis.Įvidence suggests that the microbiome, a community of microorganisms living inside the body, is altered in women with endometriosis. Endometriosis develops when lining inside the womb grows attached to surrounding tissues, such as the intestine or the membrane lining the abdominal cavity, causing bleeding, pain and other symptoms. About 196 million women worldwide suffer from endometriosis, a condition that typically causes pelvic pain and infertility.
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